Assignment 25: Abstract 4-9-18:
How reliably can pharmacogenomics be used to create an accurate and precise genetic profile that I could implement in a forensic setting? Throughout a year spent in a pharmacogenomics (PGX) laboratory and through my research into DNA genetic profiling for forensic, I have ascertained an answer to that. Despite the fact that both PGX and DNA profiling have similar standard operating procedures (SOPs), they result in wildly different data to analyze. This has some to do with the different genes they look at and some to do with the different purposes to their SOPs. The main reason that I am looking into this essential question is to present a solution to one of the main problems with DNA profiling: identifying different sources of DNA in the gathered sample. Some DNA full profiles are later on found to be a collection of partial profiles that just looked like a full profile. Unfortunately, PGX runs into the same problem that DNA profiling does. It cannot ascertain between different sources within the same sample. Otherwise, PGX can create an accurate and precise genetic profile. Implementing it in a forensic setting is futile, though, because it does no better at solving the same problem that DNA profiling runs into.
How reliably can pharmacogenomics be used to create an accurate and precise genetic profile that I could implement in a forensic setting? Throughout a year spent in a pharmacogenomics (PGX) laboratory and through my research into DNA genetic profiling for forensic, I have ascertained an answer to that. Despite the fact that both PGX and DNA profiling have similar standard operating procedures (SOPs), they result in wildly different data to analyze. This has some to do with the different genes they look at and some to do with the different purposes to their SOPs. The main reason that I am looking into this essential question is to present a solution to one of the main problems with DNA profiling: identifying different sources of DNA in the gathered sample. Some DNA full profiles are later on found to be a collection of partial profiles that just looked like a full profile. Unfortunately, PGX runs into the same problem that DNA profiling does. It cannot ascertain between different sources within the same sample. Otherwise, PGX can create an accurate and precise genetic profile. Implementing it in a forensic setting is futile, though, because it does no better at solving the same problem that DNA profiling runs into.